It's the stage of the cup when NIFL Premiership teams join the competition.
Rathfriland Rangers travel to Seaview to face Crusaders, while Immaculata have an away tie with Cliftonville.
Other notable fixtures see Banbridge Town host Carrick Rangers, Wakehurst travel to Portadown, and Linfield face Ballymena.
Who will progress to the 6th round and a move a step closer to the showpiece final in May?
A full fixture list is below:
